NFL Picks: Week 2 Best Bets

Two former Oklahoma quarterbacks who were drafted No. 1 overall will square off when Kyler Murray and the Arizona Cardinals take on Baker Mayfield and the Cleveland Browns on Sunday. The No. 1 pick in the 2018 draft, Mayfield has the Browns (3-2) in a tie for second place in the AFC North. Murray, the No. 1 pick in 2019, and the Cardinals (5-0) are the NFL's last remaining undefeated team. On Sunday, Arizona will be without coach Kliff Kingsbury, quarterback coach Cam Turner and defensive lineman Zach Allen, who all tested positive for COVID-19. Cleveland is a 3.5-point favorite in the latest NFL odds from Caesars Sportsbook, but which side should you back with your NFL bets and NFL parlays?

Other key NFL matchups include the four AFC division leaders squaring off: the Ravens hosting the Chargers on Sunday and the Bills meeting the Titans on Monday night. Before making any Week 6 NFL picks or predictions, you need to check out the NFL best bets from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 6. If you successfully parlay its picks, you'd be looking at a massive payout of 25-1. You can only see the model's Week 6 NFL picks at SportsLine

Week 6 NFL picks, odds, 2021 best bets from proven model: This five-way football parlay would pay out 25-1

Source:CBSSports.com

Week 6 NFL picks, odds, 2021 best bets from proven model: This five-way football parlay would pay out 25-1

Packers vs. Bears odds, spread, line, predictions: 2021 NFL picks, Week 6 best bets from model on 125-83 run

Source:CBSSports.com

Packers vs. Bears odds, spread, line, predictions: 2021 NFL picks, Week 6 best bets from model on 125-83 run

Week 5 best bets: NFL picks and predictions for Sundays games

Source:USA Today

Week 5 best bets: NFL picks and predictions for Sundays games

Cowboys vs. Patriots odds, picks, line, how to watch, live stream: Model reveals 2021 Week 6 NFL predictions

Source:CBS Sports on MSN.com

Cowboys vs. Patriots odds, picks, line, how to watch, live stream: Model reveals 2021 Week 6 NFL predictions

NFL Week 6 game picks, schedule guide, fantasy football tips, odds, injuries and more

Source:ESPN

NFL Week 6 game picks, schedule guide, fantasy football tips, odds, injuries and more

NFL odds Week 6 best bets: A four-team, seven-point teaser (and more)

Source:Fox Sports

NFL odds Week 6 best bets: A four-team, seven-point teaser (and more)